Natalie Portman, Kiefer Sutherland, the White Stripes and Dr. Phil McGraw will be among the guest voices on the upcoming season of "The Simpsons."

Joe Mantegna will reprise his role as Springfield's infamous mob boss Fat Tony when the animated Fox show begins its 18th season September 10. Joe Pantoliano and Michael Imperioli guest-star as Fat Tony's main thugs, the network announced Monday.

The White Stripes voice themselves in the September 17 episode when Bart organizes a benefit concert to repair his arm that was mangled by a tiger Lisa rescued from the local pound.

McGraw, Fran Drescher and comedian Richard Lewis guest-star in a Halloween episode on November 5.

Sutherland voices a hard-nosed colonel when Homer lands in basic training on November 12.

Also paying a visit to Springfield will be authors Tom Wolfe, Gore Vidal, Michael Chabon and Jonathan Franzen.

In May, the Emmy-winning series will air its 400th episode.

I heard the waiting list for celebrities to appear on the Simpsons was absolutely ridiculous. They've had so many guests on that show in the past...

The simpsons are my has inspired my saracsm. I love the show. I love the cameos..the best was george bush SR

everyone who is anyone wants to be part of that historical show.